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Selenium is a cofactor for enzymes that are present in thyroid cells, such as iodothyronine deiodinase (DIO), which catalyzes the conversion of T4 to T3, thioredoxin reductase (TR), which is involved in the regulation of the redox state, and glutathione peroxidase (GPx), which catalyzes the reduction of H 2 O 2 to H 2 O, using reduced glutathione (GSH) as a cosubstrate

Peroxisome proliferator-activated receptors (PPARs) regulate triglycerides (TGs), blood sugar, and abdominal adiposity

In some embodiments, the otic formulation or composition comprises about 0.05% by weight of the povidone

[2] FDA Guidance for Industry: Sterile Drug Products Produced by Aseptic Processing